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队伍概况

 

   

姓名

柯少勇

所在单位

生物农药中心

职称/职务

副研究员/研究室主任

学科专业

应用化学

研究方向

药物的化学生物学

联系电话

02759101956

电子信箱

shaoyong.ke@nberc.com

主要学习及工作经历:

1998.09-2002.07,本科毕业于华中师范大学化学学院,获理学学士学位;

2002.09-2005.07,硕士毕业于上海师范大学生命与环境科学学院,获理学硕士学位;

2005.09-2009.03,博士毕业于华东理工大学药学院,应用化学专业,获工学博士学位;期间于2008.02-2008.09在大连理工大学环境与生命学院从事分子生物学试验研究;

2009.04-2011.11,ca88亚洲城官网生物农药中心,助理研究员;

2011.12-至今,ca88亚洲城官网生物农药中心,副研究员。

主要社会兼职情况:

美国化学学会会员,亚洲科学编辑委员会会员、BENTHAM AMBASSADOR、国际期刊Chemical Biology LettersAcademia Journal of Agricultural Research编委,Mini-Reviews in Medicinal Chemistry副编委,中国科技论文在线特聘专家,波兰基金项目海外评审,陕西省自然基金评审专家美国化学会(ACS)、英国皇家化学会(RSC)、中国化学会(CCSNatureWileyElsevierSpringLinkBenthamTaylor and Francis等国际出版社主办的三十余种SCI源刊论文评审专家

目前主要研究领域:

微生物资源导向的农药及药物的先导发现及化学生物学

主持及参与项目(课题)情况(主要科技项目5项):

1.       烟草废弃物导向的功能型农用组合物开发(2018SNH07,横向课题,2018.10-2019.06

2.       天然产物导向的农药先导发现,ca88领军人才计划项目,2017.12-2022.11

3.       农业生物药物分子靶标发现与绿色药物分子设计(2017YFD0200502),国家化学肥料和农药减施增效综合技术研发重点专项,2017.7-2020.12

4.       杂环亚胺作为新型杀虫剂的先导优化及应用研究(2016020101010093),武汉市应用基础研究计划项目,2016.8-2018.8

5.       PI3K/Akt信号通路在DHEA衍生物抗EV71中的作用研究(31400153),国家自然科学基金,2015.1-2017.12

获得的科技奖励及专利、标准情况:

任职以来,荣获湖北省科技进步一等奖、湖北省自然科学优秀论文奖、湘鄂赣农业科研杰出青年优秀奖、省农科院先进工作者、省农科院学术报告会一等奖、省农科院青年奖励基金等,并入选ca88亚洲城官网首批领军人才计划;以第一发明人申报国际PCT专利2项,国内发明专利10项,第二发明人申报国内发明专利3项。

1.       柯少勇等. 具有杀虫活性的肟醚或酯衍生物及其制备方法与应用. 授权专利: ZL201010518800.4, 2014.

2.       柯少勇等. 含氮杂环亚胺衍生物及其制备方法和用途. 授权专利: ZL201210171077.6, 2015.

3.       柯少勇等. 共轭双烯衍生物及其制备方法与作为抗癌药物的用途. 授权专利: ZL201310350441.X, 2016.

4.       柯少勇等. 具有双腙结构的甾体衍生物作为抗病毒药物的应用. 授权专利: ZL201410053947.9, 2017.

5.       柯少勇等. 含双酰胺结构的杂环亚胺衍生物及其制备方法和用途. 授权专利: ZL201610079057.4, 2018.

6.       Ke SY, et al. Conjugated diene derivatives, preparation method therefor, and uses thereof as anticancer drug. PCT Intl. Appl. WO2015021833A1, 2015.

7.       Ke SY, et al. Nitrogenous Heterocyclic Imide Derivative and Preparation Method and Use Thereof. PCT Intl. Appl. WO2013177985A1, 2013.

8.       柯少勇等. α-氨基酮结构的酰胺衍生物及其制备方法和用途. 申请专利: CN201710207603.2, 2017.

9.       柯少勇等. 一种含噻唑杂环的甾体衍生物及其制备方法与应用. 申请专利: CN201810114536.4, 2018.

10.   柯少勇等. 酰胺衍生物及其制备方法和用途. 申请专利: CN201910472351.5, 2019.

11.   柯少勇等. 一种含靛红单元的甾体衍生物及其制备方法与用途. 申请专利: CN201910115723.9, 2019.

代表性著作及论文发表情况:

1.         Xu T, Shi L, Zhang Y, Wang K, Yang Z*, Ke S*, Synthesis and biological evaluation of marine alkaloid-oriented β-carboline analogues, Eur. J. Med. Chem., 2019, 168, 293-300.

2.         Ke S*, Zhang Z, Shi L, Liu M, Fang W, Zhang Y, Wu Z, Wan Z, Long T, Wang K*, An efficient synthesis and bioactivity evaluation of oxazole-containing natural Hinduchelins A-D and their derivatives, Org. Biomol. Chem., 2019, 17, 3635-3639.

3.         柯少勇, 吴兆圆, 万中义, 方伟, 张亚妮, 王开梅*, 具有农药活性的微生物源核苷类化合物, 化学进展, 2019, 31, 954-968.

4.         Wang S, Bao L, Song D, Wang J, Cao X*, Ke S*, Amino acid-oriented poly-substituted heterocyclic tetramic acid derivatives as potential antifungal agents, Eur. J. Med. Chem., 2019, 179, 567-575.

5.         Ke S*, Li N, Ke T, Shi L, Zhang Z, Fang W, Zhang Y, Wang K, Zhou R, Wan Z, Yang Z, Zhang G, Wei Y*, Synthesis and evaluation of steroidal thiazoline conjugates as potential antiviral agents, Future Med. Chem., 2018, 10, 2589-2605.

6.         Ke S*, Recent progress of novel steroid derivatives and their potential biological properties, Mini-Rev. Med. Chem., 2018, 18, 745-775.

7.         Ke S*, Ke T, Zhang Z, Shi L, Huang D, Wang K, Yang Z, Yang N*, Acaricidal activity and structure-activity relationships of spiro-butyrolactone derivatives against Tetranychus cinnatarinus, J. Asia-Pac. Entomol., 2018, 21, 926-929.

8.         Ke S*, Shi L, Zhang Z, Yang Z, Steroidal[17,16-d]pyrimidines derived from dehydroepiandrosterone: A convenient synthesis, antiproliferation activity, structure-activity relationships, and role of heterocyclic moiety, Sci. Rep., 2017, 7, 44439.

9.         Peng M, Shi L, Ke S*, Nicotinamide-based diamides derivatives as potential cytotoxic agents: Synthesis and biological evaluation, Chem. Cent. J., 2017, 11, 109.

10.     Ke S, Convenient structural diversity-guided synthesis of functionalized sulfur-containing heterocycles via α-substituted cyanoacetamides, J. Heterocyclic Chem., 2017, 54, 1957-1962.

11.     Yang Q, Mao Q, Liu M, Wang K, Wu Z, Fang W, Yang Z, Luo P, Ke S*, Shi L*, The inhibitory effect of dehydroepiandrosterone and its derivatives against influenza A virus in vitro and in vivo, Arch. Virol., 2016, 161, 3061-3072.

12.     Ke S, Novel amide-type ligand bearing bis-pyridine cores: Synthesis, spectral characterizations and X-ray structure analyses, J. Mol. Struct., 2016, 1118, 91-97.

13.     Yu X, Shi L, Ke S*, Acylhydrazone derivatives as potential anticancer agents: Synthesis, bio-evaluation and mechanism of action, Bioorg. Med. Chem. Lett., 2015, 25, 5772-5776.

14.     Ke S*, Shi L, Yang Z, Discovery of novel isatin-dehydroepiandrosterone conjugates as potential anticancer agents, Bioorg. Med. Chem. Lett., 2015, 25, 4628-4631.

15.     Wei Y, Shi L, Wang K, Liu M, Yang Q, Yang Z*, Ke S*, Discovery of gramine derivatives that inhibit the early stage of EV71 replication in vitro, Molecules, 2014, 19, 8949-8964.

16.     Ke S*, Yang Z, Zhang Z, Liang Y, Wang K, Liu M, Shi L*, Multisubstituted indole-acrylonitrile hybrids as potential cytotoxic agents, Bioorg. Med. Chem. Lett., 2014, 24, 1907-1911.

17.     Ke S*, Wei Y, Shi L, Yang Q, Yang Z*, Synthesis of novel steroid derivatives derived from dehydroisoandrosterone as potential anticancer agents, Anti-Cancer Agents Med. Chem., 2013, 13, 1291-1298.

18.     Ke S*, Wei Y, Yang Z, Wang K, Liang Y, Shi L*, Novel cycloalkylthiophene-imine derivatives bearing benzothiazole scaffold: Synthesis, characterization and antiviral activity evaluation, Bioorg. Med. Chem. Lett., 2013, 23, 5131-5134.

19.     Ke S*, Zhang Z, Long T, Liang Y, Yang Z, Novel salicylamide derivatives incorporating neonicotinoid pharmacophore: Design, synthesis, characterization, and biological evaluation, Med. Chem. Res., 2013, 22, 3621-3628.

20.     Ke S*, Shi L, Cao X, Yang Q, Liang Y, Yang Z, Heterocycle-functional gramine analogues: Solvent and catalyst-free synthesis and their inhibition activities against cell proliferation, Eur. J. Med. Chem., 2012, 54, 248-254.

21.     Shi L, Hu R, Wei Y, Liang Y, Yang Z, Ke S*, Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anti-cancer agents: Design, synthesis and biological evaluation, Eur. J. Med. Chem., 2012, 54, 549-556.

22.     Ke S, Zhang Z, Zhang Y, Shi L, Zhou R, Jiang A, Liang Y, Yang Z, Novel ether-functional spiro-tetronic acid derivatives: Molecule design, convenient synthesis and biological evaluation, Res. Chem. Intermed., 2012, 38, 1827-1837.

23.     Li S, Cao X*, Chen C, Ke S*, Novel salicylic acid-oriented thiourea-type receptors as colorimetric chemosensor: Synthesis, characterizations and selective naked-eye recognition properties, Spectrochimica Acta Part A, 2012, 96, 18-23.

24.     Ke S*, Cao X, Liang Y, Wang K, Yang Z, Synthesis and biological properties of dihydro-oxadiazine-based heterocyclic derivatives, Mini-Rev. Med. Chem., 2011, 11, 642-657.

25.     Ke S*, Zhang Y, Shu W, Zhang Z, Shi L, Liang Y, Wang K, Yang Z, Structural diversity-guided convenient construction of functionalized polysubstituted butenolides and lactam derivatives, C. R. Chim., 2011, 14, 1071-1079.

26.     Cao X, Chen C, Lu W, Ke S*, Chiral β-arylalkyl-1H-1,2,4-triazoles as demethylase inhibitors: Biological evaluation and its stereoselective interaction with sterol 14α-demethylase from Penicillium digitatum, Pestic. Biochem. Phys., 2011, 99, 189-193.

27.     Ke S, Sun T, Zhang Z, Zhang Y, Liang Y, Wang K, Yang Z, Spirodiclofen analogues as potential lipid biosynthesis inhibitors: A convenient synthesis, biological evaluation, and structure-activity relationship, Bull. Korean Chem. Soc., 2010, 31, 2315-2321.

28.     Ke S, Qian X*, Liu F, Wang N, Fan F, Li Z, Yang Q*, Diacylhydrazine derivatives as novel potential chitin biosynthesis inhibitors: Design, synthesis, and structure-activity relationship, Eur. J. Med. Chem., 2009, 44, 2985-2993.

29.     Ke S, Qian X*, Liu F, Wang N, Yang Q*, Li Z, Novel 4H-1,3,4-oxadiazin-5(6H)-ones with hydrophobic and long alkyl chains: Design, synthesis, and bioactive diversity on inhibition of monoamine oxidase, chitin biosynthesis and tumor cell, Eur. J. Med. Chem., 2009, 44, 2113-2121.

30.     Ke S, Liu F, Wang N, Yang Q*, Qian X*, 1,3,4-Oxadiazoline derivatives as novel potential inhibitors targeting chitin biosynthesis: Design, synthesis and biological evaluation, Bioorg. Med. Chem. Lett., 2009, 19, 332-335.

31.     Ke S, Li Z, Qian X*, 1,3,4-Oxadiazole-3(2H)-carboxamide derivatives as potential novel class of monoamine oxidase (MAO) inhibitors: Synthesis, evaluation and role of urea moiety, Bioorg. Med. Chem., 2008, 16, 7565-7572.

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